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Sight problems may increase dementia risk in older adults
Bradley Cooper?s Startling Prosthetics in ?Maestro? Were Done by the Same Special Effects Makeup Artist Who Did ?Bombshell? and ?Darkest Hour?
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                    [title] => Sight problems may increase dementia risk in older adults
                    [link] => https://coolnspicy.com/healthandscience/sight-problems-may-increase-dementia-risk-in-older-adults/
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                            [creator] => Tony Grantly
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                    [pubdate] => Sun, 26 Jun 2022 15:59:52 +0000
                    [category] => Health And ScienceadultsdementiaincreaseRiskSight
                    [guid] => https://coolnspicy.com/?p=25043
                    [description] => Journal Reference: Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M. De Fries, Yong-Hua Hu, Beibei Xu. The association between vision impairment and cognitive outcomes in older adults: a systematic review and meta-analysis. Aging & Mental Health, 2022; 1 DOI: 10.1080/13607863.2022.2077303 The results of the study, published in ... Read more
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Journal Reference:

  1. Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M. De Fries, Yong-Hua Hu, Beibei Xu. The association between vision impairment and cognitive outcomes in older adults: a systematic review and meta-analysis. Aging & Mental Health, 2022; 1 DOI: 10.1080/13607863.2022.2077303

The results of the study, published in the peer-reviewed journal Aging and Mental Health, highlight a need for further research to examine the impact of correcting sight problems in older adults ? for example, with glasses or cataract surgery ? to prevent cognitive problems and dementia.

?This study is among the first to evaluate the association between sight problems and cognitive outcomes in older adults through a comprehensive examination of all available population-based studies in English. Our findings add to the growing evidence that fading eyesight is a risk factor for developing dementia,? said lead author, Associate Professor Beibei Xu, from the Medical Informatics Center, at Peking University. ?Although the reasons behind this remain unclear, it suggests that diagnosing and treating eye conditions may be beneficial ? both to improve a person?s quality of life and also to potentially slow down or stop memory loss.?

Nearly one million people are estimated to be living with dementia in the UK ? and that number is set to increase over the next few decades as the population ages. By 2050, it is predicted that this figure will have jumped to 1.6 million. The cost of dementia is expected to almost double in the same timeframe, from £25bn today to £47bn in 2050. The disease has a devastating impact on people?s lives. As their disease progresses, they will experience greater memory loss and changes to their personality and behaviour. Ultimately, they will become completely dependent on others for their care.

The researchers included 16 studies including 76,373 participants, with five cross-sectional studies and 11 longitudinal studies published before April 2020. From these studies, the authors examined the relationship between visual impairment and cognitive outcomes in older adults. They found that:

?Finding ways to prevent or delay the onset of dementia could help reduce its devastating impact on the lives of affected individuals and their families, especially in light of the growing burden of the disease. Identifying modifiable risk factors is the first critical step for developing effective interventions to achieve this goal,? says Beibei Xu. ?Our new results highlight the importance of regular eye examinations for older adults ? enabling any potential problems with their vision to be spotted and treated early. They also suggest that any self-reported changes to a person?s eyesight should not be ignored.?

The authors (Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M De Fries, Yong-Hua Hu, and Beibei Xu) recommend future research is now warranted to examine the effectiveness of treating sight problems in older people to prevent cognitive impairment and dementia.

We wish to give thanks to the writer of this post for this remarkable content

Sight problems may increase dementia risk in older adults

) [summary] => Journal Reference: Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M. De Fries, Yong-Hua Hu, Beibei Xu. The association between vision impairment and cognitive outcomes in older adults: a systematic review and meta-analysis. Aging & Mental Health, 2022; 1 DOI: 10.1080/13607863.2022.2077303 The results of the study, published in ... Read more [atom_content] =>

Journal Reference:

  1. Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M. De Fries, Yong-Hua Hu, Beibei Xu. The association between vision impairment and cognitive outcomes in older adults: a systematic review and meta-analysis. Aging & Mental Health, 2022; 1 DOI: 10.1080/13607863.2022.2077303

The results of the study, published in the peer-reviewed journal Aging and Mental Health, highlight a need for further research to examine the impact of correcting sight problems in older adults ? for example, with glasses or cataract surgery ? to prevent cognitive problems and dementia.

?This study is among the first to evaluate the association between sight problems and cognitive outcomes in older adults through a comprehensive examination of all available population-based studies in English. Our findings add to the growing evidence that fading eyesight is a risk factor for developing dementia,? said lead author, Associate Professor Beibei Xu, from the Medical Informatics Center, at Peking University. ?Although the reasons behind this remain unclear, it suggests that diagnosing and treating eye conditions may be beneficial ? both to improve a person?s quality of life and also to potentially slow down or stop memory loss.?

Nearly one million people are estimated to be living with dementia in the UK ? and that number is set to increase over the next few decades as the population ages. By 2050, it is predicted that this figure will have jumped to 1.6 million. The cost of dementia is expected to almost double in the same timeframe, from £25bn today to £47bn in 2050. The disease has a devastating impact on people?s lives. As their disease progresses, they will experience greater memory loss and changes to their personality and behaviour. Ultimately, they will become completely dependent on others for their care.

The researchers included 16 studies including 76,373 participants, with five cross-sectional studies and 11 longitudinal studies published before April 2020. From these studies, the authors examined the relationship between visual impairment and cognitive outcomes in older adults. They found that:

?Finding ways to prevent or delay the onset of dementia could help reduce its devastating impact on the lives of affected individuals and their families, especially in light of the growing burden of the disease. Identifying modifiable risk factors is the first critical step for developing effective interventions to achieve this goal,? says Beibei Xu. ?Our new results highlight the importance of regular eye examinations for older adults ? enabling any potential problems with their vision to be spotted and treated early. They also suggest that any self-reported changes to a person?s eyesight should not be ignored.?

The authors (Gui-Ying Cao, Zi-Shuo Chen, Shan-Shan Yao, Kaipeng Wang, Zi-Ting Huang, He-Xuan Su, Yan Luo, Carson M De Fries, Yong-Hua Hu, and Beibei Xu) recommend future research is now warranted to examine the effectiveness of treating sight problems in older people to prevent cognitive impairment and dementia.

We wish to give thanks to the writer of this post for this remarkable content

Sight problems may increase dementia risk in older adults

[date_timestamp] => 1656259192 ) [1] => Array ( [title] => Bradley Cooper?s Startling Prosthetics in ?Maestro? Were Done by the Same Special Effects Makeup Artist Who Did ?Bombshell? and ?Darkest Hour? [link] => https://coolnspicy.com/trending-people/bradley-coopers-startling-prosthetics-in-maestro-were-done-by-the-same-special-effects-makeup-artist-who-did-bombshell-and-darkest-hour/ [dc] => Array ( [creator] => Pauline Moonlky ) [pubdate] => Sun, 26 Jun 2022 15:20:20 +0000 [category] => Trending PeopleartistbombshellBradleyCoopersDarkesteffectshourmaestroMakeupProstheticsspecialStartling [guid] => https://coolnspicy.com/?p=25035 [description] => The new Netflix biopic Maestro is filming now, intending to recount the life of famous composer and humanitarian Leonard Bernstein. It features a heavily made-up Bradley Cooper in the title role, a choice that has made some people uncomfortable due to the prosthetics used for the film. Controversial or not, though, the transformation Cooper has ... Read more [content] => Array ( [encoded] =>

The new Netflix biopic Maestro is filming now, intending to recount the life of famous composer and humanitarian Leonard Bernstein. It features a heavily made-up Bradley Cooper in the title role, a choice that has made some people uncomfortable due to the prosthetics used for the film. Controversial or not, though, the transformation Cooper has undergone for the role is striking, but that?s to be expected when one looks at the career of the man behind the makeup.

?Maestro? is getting flack for casting Bradley Cooper

Bradley Cooper filming ?Maestro? | Gotham/GC Images via Getty Images

As stated, Maestro is a biographical film telling the story of Leonard Bernstein. Bernstein was an acclaimed composer and musician, winning numerous awards for his work in film, television, and theater throughout his career. Bradley Cooper has stepped up to the task of creating a film to honor Bernstein?s legacy, starring in it while also directing and producing. After a delayed production, things have finally started shooting. The first photos from the set have emerged, too, but not all of the responses to them have been positive.

We want to thank the author of this short article for this incredible content

Bradley Cooper’s Startling Prosthetics in ‘Maestro’ Were Done by the Same Special Effects Makeup Artist Who Did ‘Bombshell’ and ‘Darkest Hour’

) [summary] => The new Netflix biopic Maestro is filming now, intending to recount the life of famous composer and humanitarian Leonard Bernstein. It features a heavily made-up Bradley Cooper in the title role, a choice that has made some people uncomfortable due to the prosthetics used for the film. Controversial or not, though, the transformation Cooper has ... Read more [atom_content] =>

The new Netflix biopic Maestro is filming now, intending to recount the life of famous composer and humanitarian Leonard Bernstein. It features a heavily made-up Bradley Cooper in the title role, a choice that has made some people uncomfortable due to the prosthetics used for the film. Controversial or not, though, the transformation Cooper has undergone for the role is striking, but that?s to be expected when one looks at the career of the man behind the makeup.

?Maestro? is getting flack for casting Bradley Cooper

Bradley Cooper filming ?Maestro? | Gotham/GC Images via Getty Images

As stated, Maestro is a biographical film telling the story of Leonard Bernstein. Bernstein was an acclaimed composer and musician, winning numerous awards for his work in film, television, and theater throughout his career. Bradley Cooper has stepped up to the task of creating a film to honor Bernstein?s legacy, starring in it while also directing and producing. After a delayed production, things have finally started shooting. The first photos from the set have emerged, too, but not all of the responses to them have been positive.

We want to thank the author of this short article for this incredible content

Bradley Cooper’s Startling Prosthetics in ‘Maestro’ Were Done by the Same Special Effects Makeup Artist Who Did ‘Bombshell’ and ‘Darkest Hour’

[date_timestamp] => 1656256820 ) [2] => Array ( [title] => The last days of the summer sale! ? Food Pharmacy [link] => https://coolnspicy.com/magazine/the-last-days-of-the-summer-sale-food-pharmacy/ [dc] => Array ( [creator] => Pauline Moonlky ) [pubdate] => Sun, 26 Jun 2022 15:18:01 +0000 [category] => MagazineDaysFoodPharmacysaleSummer [guid] => https://coolnspicy.com/?p=25030 [description] => Food Pharmacy Store AB’s privacy policy Food Pharmacy Store AB (?Food Pharmacy?) works to ensure that your privacy is protected when using our services. Food Pharmacy is responsible for the personal data that you send to us in accordance with the Data Protection Regulation (GDPR). In this privacy policy, we inform you about why and ... Read more [content] => Array ( [encoded] =>

Food Pharmacy Store AB’s privacy policy

Food Pharmacy Store AB (?Food Pharmacy?) works to ensure that your privacy is protected when using our services. Food Pharmacy is responsible for the personal data that you send to us in accordance with the Data Protection Regulation (GDPR).

In this privacy policy, we inform you about why and in what way we process personal data and how we use cookies. Here you can also read about what you as a registered person have for rights and where you can turn to with questions or comments related to Food Pharmacy’s personal data processing. The privacy policy was last updated in September 2019.

What kind of personal data do we collect?

Kund
We collect personal information that you send to us, e.g. when you place orders and contact our customer service. The personal information that you send to us can e.g. include contact information, date of birth and payment information. In addition, we may collect certain personal data from external sources, e.g. credit information and address updates. When we do customer surveys, all user information is anonymized. Our legal basis for this personal data processing is to be able to fulfill the agreement against you as a customer or to be able to fulfill obligations according to law. Personal data is stored for 3 years.

Newsletters and offers
Personal information is also collected when registering our newsletter. If you have bought an item from us before, we also process your contact information in order to be able to send out offers to you. Such processing of personal data is based on our legitimate interest. If you have been reached by unwanted mailings from us, you have, in accordance with the GDPR and the Marketing Act, always the right to oppose further mailings. You do this by clicking on the link in the email itself or by contacting us at info@foodpharmacy.se.

Membership
If you are a member of Food Pharmacy, we process your contact information and the information you provide in your profile. This processing of your personal data is required for us to be able to fulfill our obligations under the agreement / terms of membership. Personal data is stored until membership ends.

How do we use your personal information?
For the following purposes:

Where is your personal information stored?
The data are stored within the European Economic Area (EEA).

What are your rights?
You have the right to request information about the personal information we have about you. If your information is incorrect, incomplete or irrelevant, you can request that it be corrected or deleted. However, we can not delete your information in cases where there is a statutory requirement for storage for e.g. accounting rules, or when there are other legal reasons why the data must be saved. You also have the right to contact Datainspektionen at datainspektionen@datainspektionen.se to submit a complaint.

Who has access to your personal information?
We never sell, exchange or pass on your personal information for marketing purposes to third parties outside of Food Pharmacy. Information passed on to third parties is only used to provide the above services to you, e.g. carriers in connection with the delivery of goods, media agencies for the distribution of newsletters and credit information or debt collection agencies for information checks to verify identity, credit or debt collection.

We protect your personal information
We have technical and organizational measures to protect your data from unauthorized access. We continuously adapt our security measures. Our payment agents process your card and personal data in accordance with the international security standard. You can read more about these standards on our suppliers’ websites – Klarna.se and Stripe.com.

Cookies
A cookie is a text file that is saved on your computer or mobile device and retrieved from it on subsequent visits to our website. Food Pharmacy uses cookies to improve and simplify your visit. We do not use cookies to store personal information or to spread information to third parties. You can easily delete cookies from your computer or mobile device via the browser, or surf in anonymous mode.

We use cookies from third parties to collect statistics in aggregate form in analysis tools such as Google Analytics. The cookies used are both permanent and temporary cookies (session cookies). Permanent cookies are stored as files on your computer or mobile device for a maximum of 24 months. Temporary cookies are deleted when you close the browser.

To get more information about cookies and the Electronic Communications Act, you can visit the Swedish Post and Telecom Agency’s website.

Personal data manager
Food Pharmacy Store AB is responsible for personal data for the personal data that you send to us in accordance with the Data Protection Ordinance (GDPR).

Food Pharmacy AB
Riddargatan 20
114 51 Stockholm
Email: info@foodpharmacy.se, jonna.andersson@foodpharmacy.se

We want to give thanks to the author of this post for this amazing content

The last days of the summer sale! – Food Pharmacy

) [summary] => Food Pharmacy Store AB’s privacy policy Food Pharmacy Store AB (?Food Pharmacy?) works to ensure that your privacy is protected when using our services. Food Pharmacy is responsible for the personal data that you send to us in accordance with the Data Protection Regulation (GDPR). In this privacy policy, we inform you about why and ... Read more [atom_content] =>

Food Pharmacy Store AB’s privacy policy

Food Pharmacy Store AB (?Food Pharmacy?) works to ensure that your privacy is protected when using our services. Food Pharmacy is responsible for the personal data that you send to us in accordance with the Data Protection Regulation (GDPR).

In this privacy policy, we inform you about why and in what way we process personal data and how we use cookies. Here you can also read about what you as a registered person have for rights and where you can turn to with questions or comments related to Food Pharmacy’s personal data processing. The privacy policy was last updated in September 2019.

What kind of personal data do we collect?

Kund
We collect personal information that you send to us, e.g. when you place orders and contact our customer service. The personal information that you send to us can e.g. include contact information, date of birth and payment information. In addition, we may collect certain personal data from external sources, e.g. credit information and address updates. When we do customer surveys, all user information is anonymized. Our legal basis for this personal data processing is to be able to fulfill the agreement against you as a customer or to be able to fulfill obligations according to law. Personal data is stored for 3 years.

Newsletters and offers
Personal information is also collected when registering our newsletter. If you have bought an item from us before, we also process your contact information in order to be able to send out offers to you. Such processing of personal data is based on our legitimate interest. If you have been reached by unwanted mailings from us, you have, in accordance with the GDPR and the Marketing Act, always the right to oppose further mailings. You do this by clicking on the link in the email itself or by contacting us at info@foodpharmacy.se.

Membership
If you are a member of Food Pharmacy, we process your contact information and the information you provide in your profile. This processing of your personal data is required for us to be able to fulfill our obligations under the agreement / terms of membership. Personal data is stored until membership ends.

How do we use your personal information?
For the following purposes:

Where is your personal information stored?
The data are stored within the European Economic Area (EEA).

What are your rights?
You have the right to request information about the personal information we have about you. If your information is incorrect, incomplete or irrelevant, you can request that it be corrected or deleted. However, we can not delete your information in cases where there is a statutory requirement for storage for e.g. accounting rules, or when there are other legal reasons why the data must be saved. You also have the right to contact Datainspektionen at datainspektionen@datainspektionen.se to submit a complaint.

Who has access to your personal information?
We never sell, exchange or pass on your personal information for marketing purposes to third parties outside of Food Pharmacy. Information passed on to third parties is only used to provide the above services to you, e.g. carriers in connection with the delivery of goods, media agencies for the distribution of newsletters and credit information or debt collection agencies for information checks to verify identity, credit or debt collection.

We protect your personal information
We have technical and organizational measures to protect your data from unauthorized access. We continuously adapt our security measures. Our payment agents process your card and personal data in accordance with the international security standard. You can read more about these standards on our suppliers’ websites – Klarna.se and Stripe.com.

Cookies
A cookie is a text file that is saved on your computer or mobile device and retrieved from it on subsequent visits to our website. Food Pharmacy uses cookies to improve and simplify your visit. We do not use cookies to store personal information or to spread information to third parties. You can easily delete cookies from your computer or mobile device via the browser, or surf in anonymous mode.

We use cookies from third parties to collect statistics in aggregate form in analysis tools such as Google Analytics. The cookies used are both permanent and temporary cookies (session cookies). Permanent cookies are stored as files on your computer or mobile device for a maximum of 24 months. Temporary cookies are deleted when you close the browser.

To get more information about cookies and the Electronic Communications Act, you can visit the Swedish Post and Telecom Agency’s website.

Personal data manager
Food Pharmacy Store AB is responsible for personal data for the personal data that you send to us in accordance with the Data Protection Ordinance (GDPR).

Food Pharmacy AB
Riddargatan 20
114 51 Stockholm
Email: info@foodpharmacy.se, jonna.andersson@foodpharmacy.se

We want to give thanks to the author of this post for this amazing content

The last days of the summer sale! – Food Pharmacy

[date_timestamp] => 1656256681 ) [3] => Array ( [title] => Dolly Parton, the living legend of country music [link] => https://coolnspicy.com/influential-people/dolly-parton-the-living-legend-of-country-music/ [dc] => Array ( [creator] => Harold Kent ) [pubdate] => Sun, 26 Jun 2022 15:14:00 +0000 [category] => Influential PeopleCOUNTRYDollylegendLivingmusicParton [guid] => https://coolnspicy.com/?p=25024 [description] => ?A living legend and a model of female empowerment?, this is how the Rock and Roll Hall of Fame defines Dolly Parton, American music star who after six decades of career has entered the museum that celebrates the great names of the music industryalthough the artist herself had declined the possibility a few months ago. ... Read more [content] => Array ( [encoded] =>

?A living legend and a model of female empowerment?, this is how the Rock and Roll Hall of Fame defines Dolly Parton, American music star who after six decades of career has entered the museum that celebrates the great names of the music industryalthough the artist herself had declined the possibility a few months ago.

Admired ?not only for her prolific body of work, excellent style, and philanthropic work, but also for the humor, wit, and self-deprecating grace that shine through in everything she does,? the success of her songs, as Islands in the stream, I will always love you, 9 to 5 o There was Jesusbroadened country music’s audience and “expanded the horizons of the countless artists who followed.”

Dolly Parton’s merits to enter the Hall of Fame are indisputable, despite the fact that she herself considered, upon being nominated, that she did not deserve such recognition, and the public that participates in the process has chosen her along with Eminem, Pat Benatar , Eurythmics, Lionel Richie and Carly Simon to be honored in 2022.

(You may be interested: The Library of the Future and the mysterious books we will read in a century)

Photo:

Pablo Gianinazzi / Eph

Parton is the honoree who has had to wait the longest to be a member of the museum ?although she has achieved it in the first nomination?, since the entity requires a musical career of at least 25 years as a requirement and she released her first record at the beginning from the 1960s.

?I am honored that all the people who voted for me did. And I thank the folks at the Rock and Roll Hall of Fame for sticking with me. I never wanted to cause trouble or stir up controversy,? Parton noted in a recent interview with Billboard, in which he confessed that he always thought that recognition was for the most prominent artists in rock music.

(Also: They auction an NFT of the teacher Armando Manzanero)

?Later I discovered that it is much more than that,? acknowledged Parton, who along with Brenda Lee will be the only woman to be part of the Rock and Roll Hall of Fame and the Country Music Hall of Fame at the moment.and will receive the tribute on November 5 at a ceremony at the Microsoft Theater in Los Angeles.

Recognition for Parton has come when her first novel, Run, Rose, Runwritten with James Patterson and set in the country music scene, is one of the best sellers from the list of The New York Timeswhile the album of the same title debuted in the top 10 of Billboard magazine’s country albums, thus reaching the record of having placed almost fifty works on the world list.

Dolly Parton, recognized by The Guinness World Records as the only artist to have achieved top 20 hits across seven different decades, and one of the best-selling artists in history, At the beginning of the year, it received 47 global gold and platinum certifications from countries such as the United States, Australia, the United Kingdom, Canada, Sweden, Finland, Denmark and Norway.

(Read: The story of Caleña who sang in the subway and is now on La Voz Chile)

more than fifty albums

Originally from Tennessee and born in 1946, Dolly Rebecca Parton first appeared on television at the age of 12 and made her first recordings a year later. In 1967 she rose to fame thanks to her appearance on country singer Porter Wagoner’s television show, with whom she collaborated for seven years. Parton eventually surpassed him in popularity and continued to achieve solo success, becoming a music superstar of his genre capable of achieving international acclaim.

I am honored that all those who voted for me have done so. And I thank the Hall of Fame people for sticking with me

With more than fifty albums, the singer has been an inspiration for numerous artists. But she is not only admired for her voice and her songs, but for having taken advantage of her fame and position for different charitable causes and to defend different social movements.

(Read: Maluma collaborates with Yandel and Eladio Carrion in the single ” Nunca y pico “)

During the toughest moments of the pandemic, Parton dedicated herself to reading stories online, aimed at a child audience: in 1995 she launched Dolly Parton’s Imagination Library, an initiative to encourage children’s reading thanks to which girls and boys have received more than 80 million books in Australia, Canada, the United Kingdom and the United States.

“Dolly gets a dose of her own medicine,” she posted on her social media when she received the first of Moderna’s vaccines, which she herself had helped finance with a million dollars, giving one more reason to receive the admiration of Americans. .

August 5 is Dolly Parton Day in Nashville, Tennessee (USA), and a state senator even proposed in 2021 that a statue of the artist be erected on Capitol Hill, an initiative that Parton rejected. ?I am honored by her intentions, but have asked legislative leaders to take this consideration out of budgets. Given what’s going on in the world, I think it’s inappropriate for me to be put on a pedestal.?, he stated in a statement.

MIRIAM SOTO
Reports

We want to give thanks to the author of this write-up for this incredible content

Dolly Parton, the living legend of country music

) [summary] => ?A living legend and a model of female empowerment?, this is how the Rock and Roll Hall of Fame defines Dolly Parton, American music star who after six decades of career has entered the museum that celebrates the great names of the music industryalthough the artist herself had declined the possibility a few months ago. ... Read more [atom_content] =>

?A living legend and a model of female empowerment?, this is how the Rock and Roll Hall of Fame defines Dolly Parton, American music star who after six decades of career has entered the museum that celebrates the great names of the music industryalthough the artist herself had declined the possibility a few months ago.

Admired ?not only for her prolific body of work, excellent style, and philanthropic work, but also for the humor, wit, and self-deprecating grace that shine through in everything she does,? the success of her songs, as Islands in the stream, I will always love you, 9 to 5 o There was Jesusbroadened country music’s audience and “expanded the horizons of the countless artists who followed.”

Dolly Parton’s merits to enter the Hall of Fame are indisputable, despite the fact that she herself considered, upon being nominated, that she did not deserve such recognition, and the public that participates in the process has chosen her along with Eminem, Pat Benatar , Eurythmics, Lionel Richie and Carly Simon to be honored in 2022.

(You may be interested: The Library of the Future and the mysterious books we will read in a century)

Photo:

Pablo Gianinazzi / Eph

Parton is the honoree who has had to wait the longest to be a member of the museum ?although she has achieved it in the first nomination?, since the entity requires a musical career of at least 25 years as a requirement and she released her first record at the beginning from the 1960s.

?I am honored that all the people who voted for me did. And I thank the folks at the Rock and Roll Hall of Fame for sticking with me. I never wanted to cause trouble or stir up controversy,? Parton noted in a recent interview with Billboard, in which he confessed that he always thought that recognition was for the most prominent artists in rock music.

(Also: They auction an NFT of the teacher Armando Manzanero)

?Later I discovered that it is much more than that,? acknowledged Parton, who along with Brenda Lee will be the only woman to be part of the Rock and Roll Hall of Fame and the Country Music Hall of Fame at the moment.and will receive the tribute on November 5 at a ceremony at the Microsoft Theater in Los Angeles.

Recognition for Parton has come when her first novel, Run, Rose, Runwritten with James Patterson and set in the country music scene, is one of the best sellers from the list of The New York Timeswhile the album of the same title debuted in the top 10 of Billboard magazine’s country albums, thus reaching the record of having placed almost fifty works on the world list.

Dolly Parton, recognized by The Guinness World Records as the only artist to have achieved top 20 hits across seven different decades, and one of the best-selling artists in history, At the beginning of the year, it received 47 global gold and platinum certifications from countries such as the United States, Australia, the United Kingdom, Canada, Sweden, Finland, Denmark and Norway.

(Read: The story of Caleña who sang in the subway and is now on La Voz Chile)

more than fifty albums

Originally from Tennessee and born in 1946, Dolly Rebecca Parton first appeared on television at the age of 12 and made her first recordings a year later. In 1967 she rose to fame thanks to her appearance on country singer Porter Wagoner’s television show, with whom she collaborated for seven years. Parton eventually surpassed him in popularity and continued to achieve solo success, becoming a music superstar of his genre capable of achieving international acclaim.

I am honored that all those who voted for me have done so. And I thank the Hall of Fame people for sticking with me

With more than fifty albums, the singer has been an inspiration for numerous artists. But she is not only admired for her voice and her songs, but for having taken advantage of her fame and position for different charitable causes and to defend different social movements.

(Read: Maluma collaborates with Yandel and Eladio Carrion in the single ” Nunca y pico “)

During the toughest moments of the pandemic, Parton dedicated herself to reading stories online, aimed at a child audience: in 1995 she launched Dolly Parton’s Imagination Library, an initiative to encourage children’s reading thanks to which girls and boys have received more than 80 million books in Australia, Canada, the United Kingdom and the United States.

“Dolly gets a dose of her own medicine,” she posted on her social media when she received the first of Moderna’s vaccines, which she herself had helped finance with a million dollars, giving one more reason to receive the admiration of Americans. .

August 5 is Dolly Parton Day in Nashville, Tennessee (USA), and a state senator even proposed in 2021 that a statue of the artist be erected on Capitol Hill, an initiative that Parton rejected. ?I am honored by her intentions, but have asked legislative leaders to take this consideration out of budgets. Given what’s going on in the world, I think it’s inappropriate for me to be put on a pedestal.?, he stated in a statement.

MIRIAM SOTO
Reports

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Dolly Parton, the living legend of country music

[date_timestamp] => 1656256440 ) [4] => Array ( [title] => Prep notebook: Geoff Arte replaces father Mike Arte as girls basketball coach at Gonzaga Prep [link] => https://coolnspicy.com/movie-production-companies/prep-notebook-geoff-arte-replaces-father-mike-arte-as-girls-basketball-coach-at-gonzaga-prep/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Sun, 26 Jun 2022 15:13:30 +0000 [category] => Movie Production CompaniesArtebasketballcoachfatherGeoffgirlsGonzagaMikenotebookPrepreplaces [guid] => https://coolnspicy.com/?p=25019 [description] => Gonzaga Prep hired Geoff Arte as girls basketball coach for the 2022-23 season, the school announced on June 1. He replaces his father, Mike Arte, who coached the Bullpups for 34 years before announcing his coaching retirement at the end of last season. Geoff Arte brings a wealth of coaching experience to Gonzaga Prep from ... Read more [content] => Array ( [encoded] =>

Gonzaga Prep hired Geoff Arte as girls basketball coach for the 2022-23 season, the school announced on June 1. He replaces his father, Mike Arte, who coached the Bullpups for 34 years before announcing his coaching retirement at the end of last season.

Geoff Arte brings a wealth of coaching experience to Gonzaga Prep from Central Valley, where he was the acting varsity boys basketball head coach, the current varsity head coach for boys cross country and girls track and field, and previously served as an assistant coach for girls basketball and girls cross country.

Arte garnered recognition as Greater Spokane League Coach of the Year for track and field three times and led the team to eight GSL titles. As acting boys basketball head coach, he led the team to the State 4A tournament in 2022.

?I am excited to return to Gonzaga Prep. It was one of the most transformative communities in my life and I look forward to the opportunity to provide those same experiences to students now,? Arte, a 2000 graduate of Gonzaga Prep, said in a statement prepared by the school.

Sprinters to nationals

Rogers senior Anthony Dearfield and junior Ellabelle Taylor have been invited to the Nike Outdoor Championship track and field meet June 17-19 at Hayward Field at the University of Oregon.

Taylor placed second at the State 2A track meet in the 100-meter dash and sixth in the 200.

Dearfield was the 2A regional champ in the 100 and 200 but did not participate at the state meet due to injury.

All-state girls basketball

The 25th annual Washington/North Idaho girls all-state basketball games will be held June 18 at HUB Sports Center in Liberty Lake.

Several GSL players were selected for the 3A/2A rosters, including sophomore Teryn Gardner and senior Haley Burns from Mead; University junior Eliannah Ramirez; West Valley sophomore Chloe DeHaro; Shadle Park junior Kyleigh Archer; and Clarkston sophomore Kendall Wallace.

Coeur d?Alene junior Madison Symons, who recently committed to Wyoming, is scheduled to participate, as is Post Falls junior Capri Sims and Lake City sophomore Sophia Zufelt.

Idaho adopts shot clock

The Idaho High School Activities Association finalized approval of a shot clock for boys and girls basketball in a unanimous vote at the IHSSA board of directors meeting Wednesday.

Leagues can start using a 35-second shot clock for regular-season and district tournament games as early as this year. The change will go into effect at the state tournaments for the 2023-24 season.

Washington adopted a shot clock for boys in 2009 and girls have used a clock since 1974. Utah and Montana are also instituting a clock for next season. Idaho becomes the 18th state association to adopt a shot clock.

Scholastic awards

The Washington Interscholastic Activities Association (WIAA) announced the 2021-22 Scholastic Cup Champions and two area schools were recognized.

The yearlong competition recognizes the top school in each of the six WIAA classifications based on academic, athletic and sportsmanship excellence. Points are awarded by a school?s finish in each of the WIAA/Gesa State Championships and Academic State Championships.

Pullman accumulated 1,735 points, which set a record at the 2A classification and ranks 10th on the all-time list.

The Greyhounds were buoyed by a first-place finish in girls swimming and diving and five runner-up finishes. Pullman took home academic championships in fastpitch softball and boys tennis.

St. George?s tallied three 2B academic championships in girls cross country along with boys and girls tennis. The Dragons girls track team earned an athletic championship to go with a second-place finish in boys golf and a third-place finish in girls cross country.

Other notable finishes: 4A: Gonzaga Prep (third), Central Valley (eighth). 3A: Mead (fifth), Mt. Spokane (seventh), 1A: Lakeside (eighth). 2B: Colfax (fifth), Davenport (sixth), Liberty (seventh), Chewelah (10th). 1B: Almira/Coulee-Hartline (fourth), Odessa (fifth), Oakesdale (eighth).

We want to thank the author of this short article for this remarkable content

Prep notebook: Geoff Arte replaces father Mike Arte as girls basketball coach at Gonzaga Prep

) [summary] => Gonzaga Prep hired Geoff Arte as girls basketball coach for the 2022-23 season, the school announced on June 1. He replaces his father, Mike Arte, who coached the Bullpups for 34 years before announcing his coaching retirement at the end of last season. Geoff Arte brings a wealth of coaching experience to Gonzaga Prep from ... Read more [atom_content] =>

Gonzaga Prep hired Geoff Arte as girls basketball coach for the 2022-23 season, the school announced on June 1. He replaces his father, Mike Arte, who coached the Bullpups for 34 years before announcing his coaching retirement at the end of last season.

Geoff Arte brings a wealth of coaching experience to Gonzaga Prep from Central Valley, where he was the acting varsity boys basketball head coach, the current varsity head coach for boys cross country and girls track and field, and previously served as an assistant coach for girls basketball and girls cross country.

Arte garnered recognition as Greater Spokane League Coach of the Year for track and field three times and led the team to eight GSL titles. As acting boys basketball head coach, he led the team to the State 4A tournament in 2022.

?I am excited to return to Gonzaga Prep. It was one of the most transformative communities in my life and I look forward to the opportunity to provide those same experiences to students now,? Arte, a 2000 graduate of Gonzaga Prep, said in a statement prepared by the school.

Sprinters to nationals

Rogers senior Anthony Dearfield and junior Ellabelle Taylor have been invited to the Nike Outdoor Championship track and field meet June 17-19 at Hayward Field at the University of Oregon.

Taylor placed second at the State 2A track meet in the 100-meter dash and sixth in the 200.

Dearfield was the 2A regional champ in the 100 and 200 but did not participate at the state meet due to injury.

All-state girls basketball

The 25th annual Washington/North Idaho girls all-state basketball games will be held June 18 at HUB Sports Center in Liberty Lake.

Several GSL players were selected for the 3A/2A rosters, including sophomore Teryn Gardner and senior Haley Burns from Mead; University junior Eliannah Ramirez; West Valley sophomore Chloe DeHaro; Shadle Park junior Kyleigh Archer; and Clarkston sophomore Kendall Wallace.

Coeur d?Alene junior Madison Symons, who recently committed to Wyoming, is scheduled to participate, as is Post Falls junior Capri Sims and Lake City sophomore Sophia Zufelt.

Idaho adopts shot clock

The Idaho High School Activities Association finalized approval of a shot clock for boys and girls basketball in a unanimous vote at the IHSSA board of directors meeting Wednesday.

Leagues can start using a 35-second shot clock for regular-season and district tournament games as early as this year. The change will go into effect at the state tournaments for the 2023-24 season.

Washington adopted a shot clock for boys in 2009 and girls have used a clock since 1974. Utah and Montana are also instituting a clock for next season. Idaho becomes the 18th state association to adopt a shot clock.

Scholastic awards

The Washington Interscholastic Activities Association (WIAA) announced the 2021-22 Scholastic Cup Champions and two area schools were recognized.

The yearlong competition recognizes the top school in each of the six WIAA classifications based on academic, athletic and sportsmanship excellence. Points are awarded by a school?s finish in each of the WIAA/Gesa State Championships and Academic State Championships.

Pullman accumulated 1,735 points, which set a record at the 2A classification and ranks 10th on the all-time list.

The Greyhounds were buoyed by a first-place finish in girls swimming and diving and five runner-up finishes. Pullman took home academic championships in fastpitch softball and boys tennis.

St. George?s tallied three 2B academic championships in girls cross country along with boys and girls tennis. The Dragons girls track team earned an athletic championship to go with a second-place finish in boys golf and a third-place finish in girls cross country.

Other notable finishes: 4A: Gonzaga Prep (third), Central Valley (eighth). 3A: Mead (fifth), Mt. Spokane (seventh), 1A: Lakeside (eighth). 2B: Colfax (fifth), Davenport (sixth), Liberty (seventh), Chewelah (10th). 1B: Almira/Coulee-Hartline (fourth), Odessa (fifth), Oakesdale (eighth).

We want to thank the author of this short article for this remarkable content

Prep notebook: Geoff Arte replaces father Mike Arte as girls basketball coach at Gonzaga Prep

[date_timestamp] => 1656256410 ) [5] => Array ( [title] => When the world of nanotechnology and microbreweries meet [link] => https://coolnspicy.com/healthandscience/when-the-world-of-nanotechnology-and-microbreweries-meet/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Sun, 26 Jun 2022 14:42:45 +0000 [category] => Health And SciencemeetmicrobreweriesNanotechnology [guid] => https://coolnspicy.com/?p=25014 [description] => Journal Reference: Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane M. Ouellet-Plamondon, Federico Rosei. Brewery spent grain derived carbon dots for metal sensing. RSC Advances, 2022; 12 (19): 11621 DOI: 10.1039/D2RA00048B Often considered as ?artificial atoms,? quantum dots are used in the transmission of light. With a range of interesting physicochemical properties, ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane M. Ouellet-Plamondon, Federico Rosei. Brewery spent grain derived carbon dots for metal sensing. RSC Advances, 2022; 12 (19): 11621 DOI: 10.1039/D2RA00048B

Often considered as ?artificial atoms,? quantum dots are used in the transmission of light. With a range of interesting physicochemical properties, this type of nanotechnology has been successfully used as a sensor in biomedicine or as LEDs in next generation displays. But there is a drawback. Current quantum dots are produced with heavy and toxic metals like cadmium. Carbon is an interesting alternative, both for its biocompatibility and its accessibility.

An eco-responsible approach

The choice of brewery waste as a source material came from Daniele Benetti, a postdoctoral fellow at INRS, and Aurel Thibaut Nkeumaleu, the master?s student at ÉTS who conducted the work. Basically, they wanted to carry out various experiments using accessible materials. This is how the scientists came to collaborate with the Brasseurs de Montréal to obtain their cereal residues.

?The use of spent grain highlights both an eco-responsible approach to waste management and an alternative raw material for the synthesis of carbon quantum dots, from a circular economy perspective,? says Professor Rosei.

The advantage of using brewery waste as a source of carbon quantum dots is that it is naturally enriched with nitrogen and phosphorus. This avoids the need for pure chemicals.

?This research was a lot of fun, lighting up what we can do with the beer by-products,? says Claudiane Ouellet-Plamondon, Canada Research Chair in Sustainable Multifunctional Construction Materials at ÉTS. ?Moreover, ÉTS is located on the site of the former Dow brewery, one of the main breweries in Quebec until the 1960s. So there is a historical and heritage link to this work.?

An accessible method

In addition to using biobased material, the research team wanted to show that it was possible to produce carbon quantum dots with common means. The scientists used a domestic microwave oven to carbonize the spent grain, resulting in a black powder. It was then mixed with distilled water and put back into the microwave oven. A passage in the centrifuge and advanced filtration allowed to obtain the quantum dots. Their finished product was able to detect and quantify heavy metals, as well as other contaminants that affect water quality, the environment and health.

The next steps will be to characterize these carbon quantum dots from brewery waste, beyond proof of concept. The research team is convinced that this nanotechnology has the potential to become sophisticated detection sensors for various aqueous solutions, even in living cells.

About the study

The paper ?Brewery spent grain derived carbon dots for metal sensing,? by Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane Ouellet-Plamondon, and Federico Rosei, was published on April 14, 2022, in the Royal Society of Chemistry journal RSC Advances. The study was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), the Quebec Centre for Advanced Materials (QCAM) and the Canada Research Chairs.

We want to thank the writer of this article for this amazing web content

When the world of nanotechnology and microbreweries meet

) [summary] => Journal Reference: Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane M. Ouellet-Plamondon, Federico Rosei. Brewery spent grain derived carbon dots for metal sensing. RSC Advances, 2022; 12 (19): 11621 DOI: 10.1039/D2RA00048B Often considered as ?artificial atoms,? quantum dots are used in the transmission of light. With a range of interesting physicochemical properties, ... Read more [atom_content] =>

Journal Reference:

  1. Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane M. Ouellet-Plamondon, Federico Rosei. Brewery spent grain derived carbon dots for metal sensing. RSC Advances, 2022; 12 (19): 11621 DOI: 10.1039/D2RA00048B

Often considered as ?artificial atoms,? quantum dots are used in the transmission of light. With a range of interesting physicochemical properties, this type of nanotechnology has been successfully used as a sensor in biomedicine or as LEDs in next generation displays. But there is a drawback. Current quantum dots are produced with heavy and toxic metals like cadmium. Carbon is an interesting alternative, both for its biocompatibility and its accessibility.

An eco-responsible approach

The choice of brewery waste as a source material came from Daniele Benetti, a postdoctoral fellow at INRS, and Aurel Thibaut Nkeumaleu, the master?s student at ÉTS who conducted the work. Basically, they wanted to carry out various experiments using accessible materials. This is how the scientists came to collaborate with the Brasseurs de Montréal to obtain their cereal residues.

?The use of spent grain highlights both an eco-responsible approach to waste management and an alternative raw material for the synthesis of carbon quantum dots, from a circular economy perspective,? says Professor Rosei.

The advantage of using brewery waste as a source of carbon quantum dots is that it is naturally enriched with nitrogen and phosphorus. This avoids the need for pure chemicals.

?This research was a lot of fun, lighting up what we can do with the beer by-products,? says Claudiane Ouellet-Plamondon, Canada Research Chair in Sustainable Multifunctional Construction Materials at ÉTS. ?Moreover, ÉTS is located on the site of the former Dow brewery, one of the main breweries in Quebec until the 1960s. So there is a historical and heritage link to this work.?

An accessible method

In addition to using biobased material, the research team wanted to show that it was possible to produce carbon quantum dots with common means. The scientists used a domestic microwave oven to carbonize the spent grain, resulting in a black powder. It was then mixed with distilled water and put back into the microwave oven. A passage in the centrifuge and advanced filtration allowed to obtain the quantum dots. Their finished product was able to detect and quantify heavy metals, as well as other contaminants that affect water quality, the environment and health.

The next steps will be to characterize these carbon quantum dots from brewery waste, beyond proof of concept. The research team is convinced that this nanotechnology has the potential to become sophisticated detection sensors for various aqueous solutions, even in living cells.

About the study

The paper ?Brewery spent grain derived carbon dots for metal sensing,? by Aurel Thibaut Nkeumaleu, Daniele Benetti, Imane Haddadou, Michael Di Mare, Claudiane Ouellet-Plamondon, and Federico Rosei, was published on April 14, 2022, in the Royal Society of Chemistry journal RSC Advances. The study was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), the Quebec Centre for Advanced Materials (QCAM) and the Canada Research Chairs.

We want to thank the writer of this article for this amazing web content

When the world of nanotechnology and microbreweries meet

[date_timestamp] => 1656254565 ) [6] => Array ( [title] => Modeling a devastating childhood disease on a chip [link] => https://coolnspicy.com/healthandscience/modeling-a-devastating-childhood-disease-on-a-chip/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Sun, 26 Jun 2022 13:25:42 +0000 [category] => Health And Sciencechildhoodchipdevastatingdiseasemodeling [guid] => https://coolnspicy.com/?p=25009 [description] => Journal Reference: Bein, A., Fadel, C.W., Swenor, B. et al. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat. Biomed. Eng, 2022 DOI: 10.1038/s41551-022-00899-x Now, a team of researchers at the Wyss Institute at Harvard University has created an in vitro human model of EED in a microengineered Intestine Chip ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Bein, A., Fadel, C.W., Swenor, B. et al. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat. Biomed. Eng, 2022 DOI: 10.1038/s41551-022-00899-x

Now, a team of researchers at the Wyss Institute at Harvard University has created an in vitro human model of EED in a microengineered Intestine Chip device, providing a window into the complex interplay between malnutrition and genetic factors driving the disease. Their EED Chips recapitulate several features of EED found in biopsies from human patients, including inflammation, intestinal barrier dysfunction, reduced nutrient absorption, and atrophy of the villi (tiny hair-like projections) on intestinal cells.

They also found that depriving healthy Intestine Chips of two crucial nutrients ? niacinamide (a vitamin) and tryptophan (an essential amino acid) ? caused morphological, functional, and genetic changes similar to those found in EED patients, suggesting that their model could be used to identify and test the effects of potential treatments.

?Functionally, there is something very wrong with these kids? digestive system and its ability to absorb nutrients and fight infections, which you can?t cure simply by giving them the nutrients that are missing from their diet. Our EED model allowed us to decipher what has happened to the intestine, both physically and genetically, that so dramatically affects its normal function in patients with EED,? said co-first author Amir Bein, R.D., Ph.D., a former Senior Postdoctoral Research Fellow at the Wyss Institute who is now the VP of Biology at Quris Technologies.

The research is published today in Nature Biomedical Engineering.

Modeling a complex disease on-a-chip

The EED Chip project grew out of conversations between the Wyss Institute?s Founding Director Donald Ingber, M.D., Ph.D. and the Bill and Melinda Gates Foundation, which has an established interest in supporting research to understand and treat enteric diseases. Recognizing that there had been no in vitro studies of EED to study its molecular mechanisms, a Wyss team of more than 20 people set about creating a model of EED using its Human Organ Chip technology developed in Ingber?s lab.

They started with the Wyss Institute?s Intestine Chips, first developedin 2012, which consist of parallel hollow microfluidic channels running through a flexible polymer material. One channel is lined with human intestinal epithelial cells, while the other channel is lined with human blood vessel cells. A medium mimicking blood is flowed through the blood vessel chip to keep the cells alive, and a permeable membrane between the two channels allows nutrients and chemical signals to travel between the two tissues. To replicate EED in these chips, the researchers lined the epithelial channel of Intestine Chips with cells derived from surgical biopsies of patients with EED, which the Gates Foundation helped to source from Aga Khan University in Pakistan. They also created Healthy Chips lined with intestinal epithelial cells from healthy children for comparison.

?Because EED is so prevalent in parts of the world where malnutrition and poor sanitation are big problems, it was unclear what role, if any, genetics or epigenetics plays in the disease. We knew that there was a group of patients who just don?t respond to nutrition, and thought that cells from their intestines might respond differently to malnutrition when compared to cells from the intestines of healthy children,? said co-first author Cicely Fadel, M.D., Ph.D., an Attending Neonatologist at Beth Israel Deaconess Medical Center, Instructor in Pediatrics at Harvard Medical School (HMS), and former Clinical Fellow working with Ingber at the Wyss Institute. She and her co-authors aimed to solve that mystery by studying the gene expression patterns of the cells in their EED Chips vs. Healthy Chips.

The team found that 287 genes in the EED Chips showed different expression levels. Among them were genes associated with inflammation, intestinal injury, and the junctions between cells. When they compared the EED Chips? genetic profile with a clinical genetic signature from patients with EED whose disease was not resolved by nutritional intervention, they found some overlap between the genes on their chips and the genes in the samples.

Then, to mimic the malnutrition that many EED patients experience, they changed the medium that was supplying nutrients to their chips by removing niacinamide and tryptophan, both of which are crucial to healthy growth in children and maintenance of health in adults.

The effect was striking.

When they were cultured with a nutrient deficiency, the Healthy Chips displayed 690 genes with different expression patterns compared to their counterparts that got full nutrition, and in the EED Chips, a whopping 969 genes had different expression patterns. Six of the top ten genes that were upregulated in the clinical EED gene signature from patient biopsies were also upregulated in the EED Chips cultured with nutrient deficiency.

?The agreement between our nutrient-deficient EED Chip signature and the signature found in human patients was really exciting. We are not only able to recreate EED intestinal form and function, but we are also doing it using the same genetic pathways that are operating in human patients. That opens up the possibility that we could test drugs and other treatments on the EED Chip and get a response that could be similar to what you would see in patients,? said Fadel.

Teasing out nature vs. nurture

The scientists then analyzed the chips from multiple angles to determine exactly which differences between the EED Chips and Healthy Chips were caused by nutrient deficiency alone versus inherent gene expression differences.

Some effects of nutritional deficiency seemed to affect the Healthy and EED Chips equally. Both types of chips displayed an upregulation of certain genetic pathways associated with inflammatory chemokine production and amino acid starvation responses, dramatically reduced growth of the villus-like structures normally found on their surfaces, and produced a much thinner mucus layer. Both types of chips became ?leaky? as the junctions between their cells were disrupted and allowed fluids to seep through and displayed changes in fatty acid absorption.

But the EED Chips displayed some unique differences in their responses to nutritional deficiency, all of which matched traits seen in human EED biopsies. The intestines of EED patients have reduced development of their internal surfaces (known as the brush border) and impaired cell growth, and the downregulation of genetic pathways associated with both of those processes were observed in the EED Chips. Paneth cells, which help regulate the microbiome in the intestine, are known to be depleted in EED patients, and Paneth cell markers were reduced in the EED Chips. Amino acids transporters were also downregulated.

The team found that EED Chips produced lower levels of inflammatory cytokines compared to Healthy Chips grown under the same conditions. But once both chips were exposed to nutritional deficiency, the EED Chips produced significantly more cytokines compared to Healthy Chips. Inflamed tissue requires more calories to maintain and renew, and EED patients with gut chronic inflammation may not be able to consume enough calories to both maintain their tissues and support their growth, contributing to stunting. This inflammation may also reduce the intestine?s ability to process oral vaccines.

Even when the full range of nutrients was available, EED chips showed a reduced ability to absorb those nutrients in the epithelial channel and transfer them into the vascular channel compared to the Healthy Chips, further suggesting that the EED tissue?s function was inherently compromised.

?One of the major contributions of this study to EED research and treatment efforts is that we were able to attribute various cellular responses specifically to nutritional deficiency, genetic changes in the intestinal cells, or a combination of both ? distinctions that have not been possible to make in clinical studies or animal models,? said Bein. ?The EED gene signature by itself wasn?t enough to fully replicate EED in our chips ? the additional exposure to malnutrition was necessary. This implies that nutritional deficiency itself disrupts nutrient processing, which creates a feedback loop that further worsens nutritional uptake in EED patients.?

The team is continuing to study EED with their model, and plans to incorporate immune cells to more deeply study inflammation and its interplay with nutrition, as well as how it impacts the body?s response to vaccines. They are also working on adding a microbiome from patients with EED to the chips to study how changes to the microbiome can affect the disease.

?Every regular meeting that our team has had with the Gates Foundation about this project over the years has started with a slide show of real children who are suffering from EED. Those children are our customers ? patients drive everything that we do at the Wyss Institute, and motivate us to work hard, often for years, on creating solutions to difficult problems that can dramatically improve their quality of life. We won?t rest until we?ve found that solution,? said Ingber, who is also the Judah Folkman Professor of Vascular Biology at HMS and Boston Children?s Hospital (BCH), as well as the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard?s John A. Paulson School of Engineering and Applied Sciences (SEAS).

Additional authors of the paper include former Wyss Institute members Ben Swenor, Wuji Cao, Rani Powers, Diogo Camacho, Sanjay Sharma, Sasan Jalili-Firoozinezhad, Jennifer Grant, and Rachelle Prantil-Baun; current Wyss Institute members Arash Naziripour, Nina LoGrande, Seongmin Kim, and Girija Goyal; Andrew Parsons from HMS, David Breault from HMS, BCH, and the Harvard Stem Cell Institute; Junaid Iqbal and Asad Ali from Aga Khan University; Lee Denson from Cincinnati Children?s Hospital Medical Center and the University of Cincinnati College of Medicine; and Sean Moore from University of Virginia.

This research was supported by the Bill and Melinda Gates Foundation, the National Institutes of Health under award DK119488, the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Anne London Fellowship, and the National Center for Advancing Translational Sciences under award KL2 TR002542.

We wish to give thanks to the author of this write-up for this awesome content

Modeling a devastating childhood disease on a chip

) [summary] => Journal Reference: Bein, A., Fadel, C.W., Swenor, B. et al. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat. Biomed. Eng, 2022 DOI: 10.1038/s41551-022-00899-x Now, a team of researchers at the Wyss Institute at Harvard University has created an in vitro human model of EED in a microengineered Intestine Chip ... Read more [atom_content] =>

Journal Reference:

  1. Bein, A., Fadel, C.W., Swenor, B. et al. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat. Biomed. Eng, 2022 DOI: 10.1038/s41551-022-00899-x

Now, a team of researchers at the Wyss Institute at Harvard University has created an in vitro human model of EED in a microengineered Intestine Chip device, providing a window into the complex interplay between malnutrition and genetic factors driving the disease. Their EED Chips recapitulate several features of EED found in biopsies from human patients, including inflammation, intestinal barrier dysfunction, reduced nutrient absorption, and atrophy of the villi (tiny hair-like projections) on intestinal cells.

They also found that depriving healthy Intestine Chips of two crucial nutrients ? niacinamide (a vitamin) and tryptophan (an essential amino acid) ? caused morphological, functional, and genetic changes similar to those found in EED patients, suggesting that their model could be used to identify and test the effects of potential treatments.

?Functionally, there is something very wrong with these kids? digestive system and its ability to absorb nutrients and fight infections, which you can?t cure simply by giving them the nutrients that are missing from their diet. Our EED model allowed us to decipher what has happened to the intestine, both physically and genetically, that so dramatically affects its normal function in patients with EED,? said co-first author Amir Bein, R.D., Ph.D., a former Senior Postdoctoral Research Fellow at the Wyss Institute who is now the VP of Biology at Quris Technologies.

The research is published today in Nature Biomedical Engineering.

Modeling a complex disease on-a-chip

The EED Chip project grew out of conversations between the Wyss Institute?s Founding Director Donald Ingber, M.D., Ph.D. and the Bill and Melinda Gates Foundation, which has an established interest in supporting research to understand and treat enteric diseases. Recognizing that there had been no in vitro studies of EED to study its molecular mechanisms, a Wyss team of more than 20 people set about creating a model of EED using its Human Organ Chip technology developed in Ingber?s lab.

They started with the Wyss Institute?s Intestine Chips, first developedin 2012, which consist of parallel hollow microfluidic channels running through a flexible polymer material. One channel is lined with human intestinal epithelial cells, while the other channel is lined with human blood vessel cells. A medium mimicking blood is flowed through the blood vessel chip to keep the cells alive, and a permeable membrane between the two channels allows nutrients and chemical signals to travel between the two tissues. To replicate EED in these chips, the researchers lined the epithelial channel of Intestine Chips with cells derived from surgical biopsies of patients with EED, which the Gates Foundation helped to source from Aga Khan University in Pakistan. They also created Healthy Chips lined with intestinal epithelial cells from healthy children for comparison.

?Because EED is so prevalent in parts of the world where malnutrition and poor sanitation are big problems, it was unclear what role, if any, genetics or epigenetics plays in the disease. We knew that there was a group of patients who just don?t respond to nutrition, and thought that cells from their intestines might respond differently to malnutrition when compared to cells from the intestines of healthy children,? said co-first author Cicely Fadel, M.D., Ph.D., an Attending Neonatologist at Beth Israel Deaconess Medical Center, Instructor in Pediatrics at Harvard Medical School (HMS), and former Clinical Fellow working with Ingber at the Wyss Institute. She and her co-authors aimed to solve that mystery by studying the gene expression patterns of the cells in their EED Chips vs. Healthy Chips.

The team found that 287 genes in the EED Chips showed different expression levels. Among them were genes associated with inflammation, intestinal injury, and the junctions between cells. When they compared the EED Chips? genetic profile with a clinical genetic signature from patients with EED whose disease was not resolved by nutritional intervention, they found some overlap between the genes on their chips and the genes in the samples.

Then, to mimic the malnutrition that many EED patients experience, they changed the medium that was supplying nutrients to their chips by removing niacinamide and tryptophan, both of which are crucial to healthy growth in children and maintenance of health in adults.

The effect was striking.

When they were cultured with a nutrient deficiency, the Healthy Chips displayed 690 genes with different expression patterns compared to their counterparts that got full nutrition, and in the EED Chips, a whopping 969 genes had different expression patterns. Six of the top ten genes that were upregulated in the clinical EED gene signature from patient biopsies were also upregulated in the EED Chips cultured with nutrient deficiency.

?The agreement between our nutrient-deficient EED Chip signature and the signature found in human patients was really exciting. We are not only able to recreate EED intestinal form and function, but we are also doing it using the same genetic pathways that are operating in human patients. That opens up the possibility that we could test drugs and other treatments on the EED Chip and get a response that could be similar to what you would see in patients,? said Fadel.

Teasing out nature vs. nurture

The scientists then analyzed the chips from multiple angles to determine exactly which differences between the EED Chips and Healthy Chips were caused by nutrient deficiency alone versus inherent gene expression differences.

Some effects of nutritional deficiency seemed to affect the Healthy and EED Chips equally. Both types of chips displayed an upregulation of certain genetic pathways associated with inflammatory chemokine production and amino acid starvation responses, dramatically reduced growth of the villus-like structures normally found on their surfaces, and produced a much thinner mucus layer. Both types of chips became ?leaky? as the junctions between their cells were disrupted and allowed fluids to seep through and displayed changes in fatty acid absorption.

But the EED Chips displayed some unique differences in their responses to nutritional deficiency, all of which matched traits seen in human EED biopsies. The intestines of EED patients have reduced development of their internal surfaces (known as the brush border) and impaired cell growth, and the downregulation of genetic pathways associated with both of those processes were observed in the EED Chips. Paneth cells, which help regulate the microbiome in the intestine, are known to be depleted in EED patients, and Paneth cell markers were reduced in the EED Chips. Amino acids transporters were also downregulated.

The team found that EED Chips produced lower levels of inflammatory cytokines compared to Healthy Chips grown under the same conditions. But once both chips were exposed to nutritional deficiency, the EED Chips produced significantly more cytokines compared to Healthy Chips. Inflamed tissue requires more calories to maintain and renew, and EED patients with gut chronic inflammation may not be able to consume enough calories to both maintain their tissues and support their growth, contributing to stunting. This inflammation may also reduce the intestine?s ability to process oral vaccines.

Even when the full range of nutrients was available, EED chips showed a reduced ability to absorb those nutrients in the epithelial channel and transfer them into the vascular channel compared to the Healthy Chips, further suggesting that the EED tissue?s function was inherently compromised.

?One of the major contributions of this study to EED research and treatment efforts is that we were able to attribute various cellular responses specifically to nutritional deficiency, genetic changes in the intestinal cells, or a combination of both ? distinctions that have not been possible to make in clinical studies or animal models,? said Bein. ?The EED gene signature by itself wasn?t enough to fully replicate EED in our chips ? the additional exposure to malnutrition was necessary. This implies that nutritional deficiency itself disrupts nutrient processing, which creates a feedback loop that further worsens nutritional uptake in EED patients.?

The team is continuing to study EED with their model, and plans to incorporate immune cells to more deeply study inflammation and its interplay with nutrition, as well as how it impacts the body?s response to vaccines. They are also working on adding a microbiome from patients with EED to the chips to study how changes to the microbiome can affect the disease.

?Every regular meeting that our team has had with the Gates Foundation about this project over the years has started with a slide show of real children who are suffering from EED. Those children are our customers ? patients drive everything that we do at the Wyss Institute, and motivate us to work hard, often for years, on creating solutions to difficult problems that can dramatically improve their quality of life. We won?t rest until we?ve found that solution,? said Ingber, who is also the Judah Folkman Professor of Vascular Biology at HMS and Boston Children?s Hospital (BCH), as well as the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard?s John A. Paulson School of Engineering and Applied Sciences (SEAS).

Additional authors of the paper include former Wyss Institute members Ben Swenor, Wuji Cao, Rani Powers, Diogo Camacho, Sanjay Sharma, Sasan Jalili-Firoozinezhad, Jennifer Grant, and Rachelle Prantil-Baun; current Wyss Institute members Arash Naziripour, Nina LoGrande, Seongmin Kim, and Girija Goyal; Andrew Parsons from HMS, David Breault from HMS, BCH, and the Harvard Stem Cell Institute; Junaid Iqbal and Asad Ali from Aga Khan University; Lee Denson from Cincinnati Children?s Hospital Medical Center and the University of Cincinnati College of Medicine; and Sean Moore from University of Virginia.

This research was supported by the Bill and Melinda Gates Foundation, the National Institutes of Health under award DK119488, the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Anne London Fellowship, and the National Center for Advancing Translational Sciences under award KL2 TR002542.

We wish to give thanks to the author of this write-up for this awesome content

Modeling a devastating childhood disease on a chip

[date_timestamp] => 1656249942 ) [7] => Array ( [title] => Rita Hayworth: the man who sowed Gilda?s disgrace | XLWeekly [link] => https://coolnspicy.com/celebrity/rita-hayworth-the-man-who-sowed-gildas-disgrace-xlweekly/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Sun, 26 Jun 2022 13:16:59 +0000 [category] => CelebritydisgraceGildasHayworthRitasowedXLWeekly [guid] => https://coolnspicy.com/?p=25006 [description] => FShe was a movie legend, but in private she was a shy woman who had learned to practice passive resistance against her father, who abused her when she was little and tortured her to turn her into an artist. She had no luck with men. Everyone around her was mean to her. It is true ... Read more [content] => Array ( [encoded] =>

FShe was a movie legend, but in private she was a shy woman who had learned to practice passive resistance against her father, who abused her when she was little and tortured her to turn her into an artist. She had no luck with men. Everyone around her was mean to her. It is true that her first husband, Edward Judson, helped her to change her image, but he also encouraged her to sleep with anyone who could give a boost to her career as an actress.

Her father encouraged her to go easy on the producers. she was just a girl

«I married Edward for love and he married me to make an investment. He was in charge from the beginning and for five years he treated me as if I had no brain or soul of my own », confessed Rita Hayworth years later. As for her marriage to her second husband, filmmaker Orson Welles, Rita assured her that she was tired of being a 25 percent wife. “He left me alone night after night. It was impossible to live with a genius. He was interested in everything about himself and nothing about his wife ».

We wish to thank the author of this article for this amazing material

Rita Hayworth: the man who sowed Gilda’s disgrace | XLWeekly

) [summary] => FShe was a movie legend, but in private she was a shy woman who had learned to practice passive resistance against her father, who abused her when she was little and tortured her to turn her into an artist. She had no luck with men. Everyone around her was mean to her. It is true ... Read more [atom_content] =>

FShe was a movie legend, but in private she was a shy woman who had learned to practice passive resistance against her father, who abused her when she was little and tortured her to turn her into an artist. She had no luck with men. Everyone around her was mean to her. It is true that her first husband, Edward Judson, helped her to change her image, but he also encouraged her to sleep with anyone who could give a boost to her career as an actress.

Her father encouraged her to go easy on the producers. she was just a girl

«I married Edward for love and he married me to make an investment. He was in charge from the beginning and for five years he treated me as if I had no brain or soul of my own », confessed Rita Hayworth years later. As for her marriage to her second husband, filmmaker Orson Welles, Rita assured her that she was tired of being a 25 percent wife. “He left me alone night after night. It was impossible to live with a genius. He was interested in everything about himself and nothing about his wife ».

We wish to thank the author of this article for this amazing material

Rita Hayworth: the man who sowed Gilda’s disgrace | XLWeekly

[date_timestamp] => 1656249419 ) [8] => Array ( [title] => For the film in which she stars with Anthony Hopkins, Anne Hathaway was inspired by her Jewish mother-in-law [link] => https://coolnspicy.com/celebrity/for-the-film-in-which-she-stars-with-anthony-hopkins-anne-hathaway-was-inspired-by-her-jewish-mother-in-law/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Sun, 26 Jun 2022 12:28:09 +0000 [category] => CelebrityAnneAnthonyFilmHathawayHopkinsInspiredJewishmotherinlawstars [guid] => https://coolnspicy.com/?p=24999 [description] => Jewish Link- A poignant drama starring Oscar winners Anthony Hopkins and Anne Hathaway opened to applause at Cannes, charting what director James Gray called the moment America lost its way. The Times of Israel. ?Armageddon Time?, which also features Jeremy Strong from the television series ?Succession?, is a semi-autobiographical story set in the New York ... Read more [content] => Array ( [encoded] =>

Jewish Link- A poignant drama starring Oscar winners Anthony Hopkins and Anne Hathaway opened to applause at Cannes, charting what director James Gray called the moment America lost its way. The Times of Israel.

?Armageddon Time?, which also features Jeremy Strong from the television series ?Succession?, is a semi-autobiographical story set in the New York borough of Queens in 1980, just when the Trump family and Ronald Reagan were on the rise.

Gray said that 1980, with the election of Reagan, the imminent threat of nuclear war with the Soviet Unionthe “humiliating” defeat of his hero Muhammad Ali by Larry Holmes and the murder of John Lennon in Manhattan, gave the film its title.

?I also think that was the beginning of a Market-is-God idea where, if you look at rising inequality as a global problem, it started around 1979, 1980,” he told reporters, calling it an “underrated turning point.” in History.?

Gray said it was also the end of auteur-driven New Hollywood movies in favor of blockbusters. ?Which meant the end of a certain kind of movie that I really love and am passionate about and I feel the obligation to try and continue?.

The drama presented at Cannes

The intimate family drama presented at Cannes explores big political and historical issues, such as the clan of descendants of Ukrainian Jews. They were victims of the pogroms, and decades later they find an America divided by racial and economic injustice.

Hopkins plays Paul’s doting grandfather, who continues to have trouble at his high school with his best friend Johnny, a black boy. Although both boys cut themselves in class, only Johnny faces serious consequences, as Paul’s mother (Hathaway) is on the parent-teacher council.

The boys’ paths continue to diverge when Paul’s (Strong) father pulls him out of school; so he puts him in a private academy where Fred Trump, Donald’s fatheris on the board.

The elite institution sees its mission as creating the next generation of US leaders, a site of “superpower privilege,” Gray said.

Strong, who won an Emmy for her performance in “Succession,” said that saw parallels between the themes of the series and the film.

?The TV show I work on is, in many ways, about late-stage capitalism and terminal decline in the US,? he said.

“Certainly you can find the kind of foreshadowing of all of that, in a way, the genome of that, in this movie.”

Hathaway said that her own Jewish mother-in-law, who recently died, had served as inspiration for his character, who out of deep love for his son makes a series of moral compromises.

?His legacy influences my life in profound ways which I am truly grateful for,? Hathaway said, fighting back tears.

?If I’ve done anything in terms of capturing the depth of that love and that connection? I won’t even try to put it into words because it’s beyond (words); that’s why I’m so grateful to the cinema, because it allows you to say things without words?.

favorable reviews

This is Gray’s sixth Cannes appearance; where films such as ?We Own the Night?, starring Joaquin Phoenix and Mark Wahlberg, and ?Two Lovers?, with Phoenix and Gwyneth Paltrow, premiered.

He went on to do the space odyssey ?Ad Astra? with Brad Pitt and the Amazon adventure ?The Lost City of Z? with Robert Pattinson.

Critics gave the new film rave reviews. Slate hailed “a sweet children’s fable that turns increasingly bitter and, with the help of a few historical figures, turns into monstrous things we do in the name of wanting what’s best for our children.”

The New Yorker called it ?great news?, a film that ?lovingly evokes which (Gray) appreciated while acknowledging that it was inseparable from the horrors of the time.”

The Irish Times he applauded a “memory tale that addresses the compromises many of us make to an unequal society,” calling Hopkins “wonderful in the rare role of a thoroughly good man.”

?Armageddon Time? is among the 21 films competing for the Cannes Palme d’Or top prizewhich will be awarded on May 28.

Authorized reproduction with the following mention: ©?EnlaceJudío

We want to give thanks to the author of this short article for this incredible material

For the film in which she stars with Anthony Hopkins, Anne Hathaway was inspired by her Jewish mother-in-law

) [summary] => Jewish Link- A poignant drama starring Oscar winners Anthony Hopkins and Anne Hathaway opened to applause at Cannes, charting what director James Gray called the moment America lost its way. The Times of Israel. ?Armageddon Time?, which also features Jeremy Strong from the television series ?Succession?, is a semi-autobiographical story set in the New York ... Read more [atom_content] =>

Jewish Link- A poignant drama starring Oscar winners Anthony Hopkins and Anne Hathaway opened to applause at Cannes, charting what director James Gray called the moment America lost its way. The Times of Israel.

?Armageddon Time?, which also features Jeremy Strong from the television series ?Succession?, is a semi-autobiographical story set in the New York borough of Queens in 1980, just when the Trump family and Ronald Reagan were on the rise.

Gray said that 1980, with the election of Reagan, the imminent threat of nuclear war with the Soviet Unionthe “humiliating” defeat of his hero Muhammad Ali by Larry Holmes and the murder of John Lennon in Manhattan, gave the film its title.

?I also think that was the beginning of a Market-is-God idea where, if you look at rising inequality as a global problem, it started around 1979, 1980,” he told reporters, calling it an “underrated turning point.” in History.?

Gray said it was also the end of auteur-driven New Hollywood movies in favor of blockbusters. ?Which meant the end of a certain kind of movie that I really love and am passionate about and I feel the obligation to try and continue?.

The drama presented at Cannes

The intimate family drama presented at Cannes explores big political and historical issues, such as the clan of descendants of Ukrainian Jews. They were victims of the pogroms, and decades later they find an America divided by racial and economic injustice.

Hopkins plays Paul’s doting grandfather, who continues to have trouble at his high school with his best friend Johnny, a black boy. Although both boys cut themselves in class, only Johnny faces serious consequences, as Paul’s mother (Hathaway) is on the parent-teacher council.

The boys’ paths continue to diverge when Paul’s (Strong) father pulls him out of school; so he puts him in a private academy where Fred Trump, Donald’s fatheris on the board.

The elite institution sees its mission as creating the next generation of US leaders, a site of “superpower privilege,” Gray said.

Strong, who won an Emmy for her performance in “Succession,” said that saw parallels between the themes of the series and the film.

?The TV show I work on is, in many ways, about late-stage capitalism and terminal decline in the US,? he said.

“Certainly you can find the kind of foreshadowing of all of that, in a way, the genome of that, in this movie.”

Hathaway said that her own Jewish mother-in-law, who recently died, had served as inspiration for his character, who out of deep love for his son makes a series of moral compromises.

?His legacy influences my life in profound ways which I am truly grateful for,? Hathaway said, fighting back tears.

?If I’ve done anything in terms of capturing the depth of that love and that connection? I won’t even try to put it into words because it’s beyond (words); that’s why I’m so grateful to the cinema, because it allows you to say things without words?.

favorable reviews

This is Gray’s sixth Cannes appearance; where films such as ?We Own the Night?, starring Joaquin Phoenix and Mark Wahlberg, and ?Two Lovers?, with Phoenix and Gwyneth Paltrow, premiered.

He went on to do the space odyssey ?Ad Astra? with Brad Pitt and the Amazon adventure ?The Lost City of Z? with Robert Pattinson.

Critics gave the new film rave reviews. Slate hailed “a sweet children’s fable that turns increasingly bitter and, with the help of a few historical figures, turns into monstrous things we do in the name of wanting what’s best for our children.”

The New Yorker called it ?great news?, a film that ?lovingly evokes which (Gray) appreciated while acknowledging that it was inseparable from the horrors of the time.”

The Irish Times he applauded a “memory tale that addresses the compromises many of us make to an unequal society,” calling Hopkins “wonderful in the rare role of a thoroughly good man.”

?Armageddon Time? is among the 21 films competing for the Cannes Palme d’Or top prizewhich will be awarded on May 28.

Authorized reproduction with the following mention: ©?EnlaceJudío

We want to give thanks to the author of this short article for this incredible material

For the film in which she stars with Anthony Hopkins, Anne Hathaway was inspired by her Jewish mother-in-law

[date_timestamp] => 1656246489 ) [9] => Array ( [title] => Aurora Ramazzotti: «I recommended? I lost jobs precisely because I am the daughter of Eros and Michelle Hunziker ? [link] => https://coolnspicy.com/shows/aurora-ramazzotti-i-recommended-i-lost-jobs-precisely-because-i-am-the-daughter-of-eros-and-michelle-hunziker/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Sun, 26 Jun 2022 12:26:45 +0000 [category] => ShowsAuroradaughterErosHunzikerJobslostMichellepreciselyRamazzottirecommended [guid] => https://coolnspicy.com/?p=24993 [description] => «I have never been recommended, in fact I have also lost some jobs precisely because there were those who wanted to avoid controversy. They all leave prejudiced, already from my name, the daughter of, spoiled». Aurora Ramazzotti talks about herself without filters a few days after her first live broadcast. Everything ... Read more [content] => Array ( [encoded] =>




«I have never been recommended, in fact I have also lost some jobs precisely because there were those who wanted to avoid controversy. They all leave prejudiced, already from my name, the daughter of, spoiled». Aurora Ramazzotti talks about herself without filters a few days after her first live broadcast. Everything is ready for Love Mi, the event on Tuesday 28 June to be held in Piazza Duomo in Milan and live on italia Uno è will be a good test for the daughter of Eros Ramazzotti and Michelle Hunziker. Next to her on the stage Elenoire Casalegno and Gabriele Vagnato: «It’s my first live broadcast, a great challenge. I am happy to be joined by Eleonoire Casalegno who has much more experience than me, I will rely on her» sincere words that Aurora released to Corriere della Sera. «My problem is that I never feel up to it».

Eros Ramazzotti, the videoclip of “Ama” amazes: protagonists Michelle Hunziker and Aurora VIDEO

Aurora Ramazzotti, the difficulties of being a daughter of art

An interview in which the influencer talks about the difficulties of being a daughter of art. She does not tolerate the word “recommended” that she is a double daughter of art. “Unfortunately it is in my blood, I was born there, even before I started doing this work, which then amplified this choir even more. My ‘impossible’ mission is to change people’s idea of ??me: I know that no one can please everyone, but this perception continues to hurt me. And I know that a small part of me will continue to want to change the opinion of others and prove them wrong».

He has always lived with the anxiety of not being up to par. “The work I have chosen is defined by the judgment of other people, the public decides whether to go on or not. I have so many insecurities, even for being a daughter of art. Sometimes I wonder if I have chosen the right path, behind the scenes so many things happen that cannot be said but that can be painful».

Michelle Hunziker protagonist of the new video by Eros Ramazzotti (together with Aurora): “Love changes, it evolves”

A reunited family

The video clip of the latest single has just been released: dad Eros and mum Michelle and she are the protagonists, a family video that demonstrates how, even when parents are hoping for one another, relationships can remain strong. She thought and strongly wanted the singer. “It surprised my mom and me because we found each other on set without knowing about each other. It was a heartfelt gesture». Finally after difficult years Eros and Michelle have found a new balance. «In the last year many things have changed, they are back to being friends and for me it is a wonderful feeling. Last year for the first time in many years we all celebrated my birthday together, it is a circle that closes, for me and for them; it is also a beautiful message for the many who separate and think that relationships will never be recovered»




Last updated: Sunday 26 June 2022, 12:44



© REPRODUCTION RESERVED

We would like to say thanks to the writer of this short article for this incredible web content

Aurora Ramazzotti: «I recommended? I lost jobs precisely because I am the daughter of Eros and Michelle Hunziker ”

) [summary] => «I have never been recommended, in fact I have also lost some jobs precisely because there were those who wanted to avoid controversy. They all leave prejudiced, already from my name, the daughter of, spoiled». Aurora Ramazzotti talks about herself without filters a few days after her first live broadcast. Everything ... Read more [atom_content] =>




«I have never been recommended, in fact I have also lost some jobs precisely because there were those who wanted to avoid controversy. They all leave prejudiced, already from my name, the daughter of, spoiled». Aurora Ramazzotti talks about herself without filters a few days after her first live broadcast. Everything is ready for Love Mi, the event on Tuesday 28 June to be held in Piazza Duomo in Milan and live on italia Uno è will be a good test for the daughter of Eros Ramazzotti and Michelle Hunziker. Next to her on the stage Elenoire Casalegno and Gabriele Vagnato: «It’s my first live broadcast, a great challenge. I am happy to be joined by Eleonoire Casalegno who has much more experience than me, I will rely on her» sincere words that Aurora released to Corriere della Sera. «My problem is that I never feel up to it».

Eros Ramazzotti, the videoclip of “Ama” amazes: protagonists Michelle Hunziker and Aurora VIDEO

Aurora Ramazzotti, the difficulties of being a daughter of art

An interview in which the influencer talks about the difficulties of being a daughter of art. She does not tolerate the word “recommended” that she is a double daughter of art. “Unfortunately it is in my blood, I was born there, even before I started doing this work, which then amplified this choir even more. My ‘impossible’ mission is to change people’s idea of ??me: I know that no one can please everyone, but this perception continues to hurt me. And I know that a small part of me will continue to want to change the opinion of others and prove them wrong».

He has always lived with the anxiety of not being up to par. “The work I have chosen is defined by the judgment of other people, the public decides whether to go on or not. I have so many insecurities, even for being a daughter of art. Sometimes I wonder if I have chosen the right path, behind the scenes so many things happen that cannot be said but that can be painful».

Michelle Hunziker protagonist of the new video by Eros Ramazzotti (together with Aurora): “Love changes, it evolves”

A reunited family

The video clip of the latest single has just been released: dad Eros and mum Michelle and she are the protagonists, a family video that demonstrates how, even when parents are hoping for one another, relationships can remain strong. She thought and strongly wanted the singer. “It surprised my mom and me because we found each other on set without knowing about each other. It was a heartfelt gesture». Finally after difficult years Eros and Michelle have found a new balance. «In the last year many things have changed, they are back to being friends and for me it is a wonderful feeling. Last year for the first time in many years we all celebrated my birthday together, it is a circle that closes, for me and for them; it is also a beautiful message for the many who separate and think that relationships will never be recovered»




Last updated: Sunday 26 June 2022, 12:44



© REPRODUCTION RESERVED

We would like to say thanks to the writer of this short article for this incredible web content

Aurora Ramazzotti: «I recommended? I lost jobs precisely because I am the daughter of Eros and Michelle Hunziker ”

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